First stop: WRIB in Dallas, Texas from April 13th to 17th. Visit us at the Hyatt Regency Dallas, Booth #2, where our Luminex experts will be on hand to connect with you and answer your questions.
But that’s not all! Visit us at AACR at the San Diego Convention Center in California and find us at Booth #1937 from April 19th to 22nd. We’ll kick off the meeting with our Exhibitor Spotlight on Sunday, April 19th, from 1:30–2:30 p.m. in Theater E, featuring real-world stories highlighting cytokine studies in cancer research.
The Highest xMAP® Sensitivity Yet — From Baylor College of Medicine
Researchers at Baylor College of Medicine have rigorously evaluated xMAP® Technology, identifying advanced normalization strategies and analytical optimization methods that further enhance assay sensitivity. Their work incorporates the following methodological approaches:
Introducing a three‑step normalization workflow to boost assay sensitivity and reproducibility.
Using orthogonal regression for more accurate background correction, reducing noise, and improving signal clarity.
Applying a GAM-based plate normalization method to correct machine drift more reliably than traditional linear approaches.
Implementing model‑based clustering to determine true positive/negative cut‑points for binary data.
Demonstrating higher signal‑to‑noise ratios, lower variability, and better classification accuracy across targets.
Releasing an easy‑to‑use web app so researchers can apply the full workflow in their own xMAP data analysis.
R&D Systems has decades of experience developing, optimizing, and validating the highest quality Luminex-based assays for research through the clinic. But did you know they also will work with you to produce assays tailored to your needs? Customization options include:
Gain a Better Understanding of Toxicity Biomarkers with MILLIPLEX® Toxicity Assays
Toxicity affects all facets of biological research and drug development. A guiding tenet in toxicity studies is to eliminate toxic compounds as early as possible in the drug development process. Bead-based multiplex toxicity assays enable a precise, multiparametric analysis of toxicity and its underlying processes. MILLIPLEX® multiplex toxicity biomarker assay kits enable researchers to simultaneously quantify dozens of toxicity analytes across several species (including rat, mouse, porcine, canine, and feline models).
A recent publication by Ahmadi et al. highlights a next-day, semi-automated CAR-T manufacturing process that significantly reduces production time while preserving key naïve and stem-like T-cell populations—critical for durable therapeutic responses.
To support deep immune profiling in CAR-T development, Invitrogen™ ProcartaPlex™ multiplex immunoassays were used to assess and monitor the potency of the CAR T-cells. ProcartaPlex™ multiplex immunoassays enable simultaneous measurement of up to 80 cytokines and biomarkers from minimal sample volumes, helping researchers efficiently characterize immune activation and product quality.
Resolving Persistent RAGE-driven Inflammation after Sepsis
Persistent activation of the RAGE pathway was shown to drive long-term inflammatory and mitochondrial dysfunction following sepsis in a Scientific Reports study. To accurately assess chronic immune signaling, the team used Invitrogen™ QuantiGene™ multiplex gene expression assays to directly quantify inflammatory and metabolic transcripts without amplification, minimizing bias and improving reproducibility in diseased muscle tissue.
This approach enabled clear resolution of persistent, low-level inflammatory gene expression that is often difficult to detect with traditional methods—demonstrating that loss of RAGE prevents long-term immune dysregulation after sepsis.
These products are for Research Use Only. Not for use in diagnostic procedures. Please contact Luminex at support@luminexcorp.com to obtain the appropriate product information for your country of residence.
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